There's a surprising relationship between COPD (chronic obstructive pulmonary disease) and caffeine, and it isn't about the caffeine.
Men who have COPD, more than women, tend to have a very high threshold for sensing bitter tastes. That means that they tend to want very strong coffee or tea, because they can't taste a mild brew. The stronger the coffee, the higher the concentration of caffeine.
And since medications for COPD have to be cleared out of circulation by the same processes that the liver uses to detox steroids from inhalers, the effects of caffeine are greater in both men and women who have COPD.
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Chapman-Novakofski K, Brewer MS, Riskowski J, Burkowski C, Winter L. Alterations in taste thresholds in men with chronic obstructive pulmonary disease. J Am Diet Assoc. 1999 Dec;99(12):1536-41.